| 引用本文:刘祥1，侯季秋2，赵海滨2，孙治琪1，赵维哲1，郜亚茹2.基于“内质网-线粒体”互通论心肌梗死后抑郁“瘀虚痰热”之机[J].世界中医药,2024,(18):. |
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| 基于“内质网-线粒体”互通论心肌梗死后抑郁“瘀虚痰热”之机 |
| Mechanism of “Stasis，Deficiency，Phlegm，and Heat” in Depression after Myocardial Infarction Based on “Endoplasmic Reticulum-mitochondria” Interconnection |
| 投稿时间：2023-07-29 |
| DOI：10.3969/j.issn.1673-7202.2024.18.021 |
| 中文关键词: 心肌梗死后抑郁 机制 内质网应激 线粒体钙超载 钙稳态 瘀虚痰热 活血养血 化痰清心 |
| English Keywords:Depression after myocardial infarction Mechanisms Endoplasmic reticulum stress Mitochondrial calcium overload Calcium homeostasis Stasis,deficiency,phlegm,and heat Activating and nourishing blood Resolving phlegm and clearing the heart |
| 基金项目:国家自然科学基金项目（82174332）；北京市自然科学基金项目（7202126） |
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| 中文摘要: |
| 双心疾病主要指心脏和心理同病，心肌梗死后抑郁是常见的双心疾病。心肌梗死后，患者容易出现抑郁等不良情绪，而抑郁情绪又是诱发不良心血管事件的重要危险因素。瘀、虚、痰、热作为心肌梗死后抑郁的重要病因，可单独或相兼致病，故临床上常用活血养血、化痰清心之法以达到瘀、虚、痰、热共治的目的。同时，现代医学认为内质网应激引起线粒体相关内质网膜（MAM）钙稳态失衡是导致线粒体钙超载损伤的内在机制，本文从该角度阐释心肌梗死后抑郁的内在机制，为临床治疗提供新的参考。 |
| English Summary: |
| Psycho-cardiological disease primarily refers to the co-occurrence of cardiac and psychological disorders，with post-myocardial infarction(MI) depression being a common example.After an MI，patients often experience adverse emotions like depression，which significantly increases the risk of negative cardiovascular events.Stasis，deficiency，phlegm，and heat are key pathological factors contributing to post-MI depression，and they can act independently or synergistically.Clinically，therapies such as activating and nourishing blood，resolving phlegm，and clearing heat are commonly used to address stasis，deficiency，phlegm，and heat collectively.Moreover，modern medicine suggests that endoplasmic reticulum(ER) stress leading to imbalances in calcium homeostasis at the mitochondria-associated ER membranes(MAM) is an intrinsic mechanism causing mitochondrial calcium overload and damage.This study elucidates the underlying mechanisms of post-MI depression from this perspective and offers new insights for clinical treatment strategies. |
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