| 引用本文:彭紫凝1，邓茜1，孟凡雨1，晏蔚田2，刘念1，彭江云2.痛风“湿-热-寒-瘀-虚”复杂病机网络及生物学基础研究进展[J].世界中医药,2024,(23):. |
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| 痛风“湿-热-寒-瘀-虚”复杂病机网络及生物学基础研究进展 |
| Complex Pathogenesis Network of “Dampness-heat-cold-stasis-deficiency” in Gout and Its Biological Basis:A Review |
| 投稿时间：2024-03-30 |
| DOI：10.3969/j.issn.1673-7202.2024.23.024 |
| 中文关键词: 痛风 湿-热-寒-瘀-虚 复杂病机网络 肠道菌群紊乱 炎症反应 氧化应激 微循环障碍 免疫功能降低 |
| English Keywords:Gout “Dampness-heat-cold-stasis-deficiency” Complex pathogenesis network Intestinal flora disorder Inflammatory reaction Oxidative stress Microcirculation disorder Immune dysfunction |
| 基金项目:国家自然科学基金项目（81960863）；国家中医药管理局高水平中医药重点学科（风湿痹病学）建设项目（zyyzdxk-2023189）；云南省教育厅科学研究基金项目（2024Y380） |
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| 中文摘要: |
| 目前痛风患病率逐年上升，但是发病机制复杂，临床上缺乏切实有效的治疗药物。中医药治疗痛风疗效确切，其病机可归为“湿-热-寒-瘀-虚”网络。从中医学阐述“湿-热-寒-瘀-虚”复杂病机网络的内涵，结合现代医学肠道菌群紊乱、炎症反应、氧化应激、微循环障碍和免疫功能降低的生物学基础，为痛风中医辨证施治及防治提供参考，也为中医药的发展完善其现代内涵。 |
| English Summary: |
| The prevalence of gout has been rising year by year，but its pathogenesis is complex，and there is a lack of effective therapeutic drugs in clinical practice.Traditional Chinese medicine(TCM) has been proven to be effective in treating gout，with its pathogenesis categorized under the “dampness-heat-cold-stasis-deficiency” network.This article elaborates on the connotation of the complex pathogenesis network of “dampness-heat-cold-stasis-deficiency” from the perspective of TCM，and combines the biological basis of modern medicine，including intestinal flora imbalance，inflammatory response，oxidative stress，microcirculation disorders，and immune dysfunction，to provide a reference for TCM syndrome differentiation，treatment，and prevention of gout.This also contributes to the development of TCM and the refinement of its modern connotations. |
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