| 引用本文:王柏乔1，2，应春苗1，2，刘飞祥1，2，张运克1，2.中药调控生物钟治疗睡眠障碍的作用机制研究进展[J].世界中医药,2024,(24):. |
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| 中药调控生物钟治疗睡眠障碍的作用机制研究进展 |
| Research Progress on the Mechanism of Chinese Medicine in Regulating Biological Clock in the Treatment of Sleep Disorders |
| 投稿时间：2024-06-05 |
| DOI：10.3969/j.issn.1673-7202.2024.24.022 |
| 中文关键词: 中药 生物钟 昼夜节律 睡眠障碍 生物钟基因 神经递质 信号通路 肠道菌群 |
| English Keywords:Chinese medicine Biological clock Circadian rhythm Sleep disorder Biological clock gene Neurotransmitters Signaling pathways Gut microbiota |
| 基金项目:国家自然科学基金项目（81974564，82104730）；中原英才计划——科技创新领军人才项目（224200510027）；河南省“双一流”创建学科中医学科学研究专项（HSRP-DFCTCM-2023-1-04）；河南省中医药科学研究专项课题（2023ZY1030） |
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| 中文摘要: |
| 随着社会压力的增加和生活节奏的加快，睡眠障碍已成为一个日益严重的公共卫生问题。生物钟失调被认为是导致睡眠障碍的重要因素之一，目前西医缺乏针对生物钟方面治疗睡眠障碍的有效药物。作为具有千年历史的中医学，其“天人合一”思想及睡眠理论与生物钟理论不谋而合。近年研究发现，中药在调节生物钟治疗睡眠障碍方面展现出巨大潜力，但是相关作用机制尚未有统一定论，现有的文献研究主要集中在中药直接调控生物钟基因的作用上，缺乏中药调控生物钟治疗睡眠作用机制的系统性整理和归纳。通过回顾梳理近年国内外文献，发现中药不仅具有在调控生物钟基因方面的作用，还能够通过调控神经递质、信号通路和肠道菌群等多方面的机制调控生物钟进而改善睡眠障碍。这拓展了对中药调控生物钟治疗睡眠障碍的理解，为进一步深入研究和临床应用奠定了理论基础。 |
| English Summary: |
| With the increasing societal pressure and accelerated pace of life，sleep disorders have become an increasingly serious public health issue.Disruption of the biological clock is considered one of the key factors contributing to sleep disorders，and currently，Western medicine lacks effective drugs targeting the biological clock to treat sleep disorders.Traditional Chinese medicine(TCM)，with its millennia-old history，shares a similar perspective with the biological clock theory through its concept of “the unity of heaven and man” and its sleep theories.Recent studies have shown that Chinese medicine has significant potential in regulating the biological clock to treat sleep disorders.However，the exact mechanisms remain inconclusive.Most existing literature focuses on the direct regulation of biological clock genes by Chinese medicine，but there is a lack of systematic reviews and summaries on the mechanisms of Chinese medicine in regulating the biological clock to treat sleep disorders.By reviewing recent literature in China and abroad，it was found that Chinese medicine not only affects the regulation of biological clock genes but also regulates the biological clock through multiple mechanisms，such as neurotransmitter modulation，signaling pathways，and gut microbiota，thereby improving sleep disorders.This expands our understanding of regulation of the biological clock in treating sleep disorders by Chinese medicine and provides a theoretical foundation for further research and clinical application. |
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