| 引用本文:魏秀秀1，张北华2，马祥雪2，尹晓岚2，刘佳丽2，徐陆周1，唐旭东2.肠道菌群与胃食管反流病的相关性研究进展[J].世界中医药,2024,(24):. |
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| 肠道菌群与胃食管反流病的相关性研究进展 |
| Research Progress on the Correlation Between Gut Microbiota and Gastroesophageal Reflux Disease |
| 投稿时间：2023-10-25 |
| DOI：10.3969/j.issn.1673-7202.2024.24.025 |
| 中文关键词: 肠道菌群 胃食管反流病 黏膜屏障 胃肠动力 内脏高敏感 研究进展 中医药 炎症反应 |
| English Keywords:Gut microbiota Gastroesophageal reflux disease Mucosal barrier Gastrointestinal motility Visceral hypersensitivity Research progress Traditional Chinese medicine Inflammatory response |
| 基金项目:国家重点研发计划项目（2019YFC1709600）；国家自然科学基金青年项目（82004356）；国家中医药传承创新团队及人才支持计划项目（ZYYCXTD-C-202010）；江苏省中医院优秀青年博士培养计划项目（2024QB040）；第五批全国中医临床优秀人才研修项目（国中医药人教函〔2022〕1号） |
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| 中文摘要: |
| 肠道菌群作为人类的第二基因组，与人类健康和疾病息息相关，正在成为影响人类健康和疾病的关键参与者。胃食管反流病（GERD）是一种常见的慢性消化系统疾病，可以引起肠道菌群改变。越来越多的研究表明，肠道菌群影响GERD发展的炎症反应介导的黏膜屏障、胃肠动力、内脏高敏感等，可通过粪菌移植、微生态制剂以及中医药疗法以调节肠道菌群，将肠道菌群作为GERD干预靶点。 |
| English Summary: |
| The gut microbiota，as the second genome of humans，is closely related to human health and diseases，and is becoming a key participant in influencing human health and disease.Gastroesophageal reflux disease(GERD) is a common chronic digestive system disorder that can lead to alterations in the gut microbiota.Increasing research shows that the gut microbiota affects the development of GERD through mechanisms such as inflammatory response-mediated mucosal barrier disruption，gastrointestinal motility，and visceral hypersensitivity.Interventions like fecal microbiota transplantation，microbiome-based preparations，and traditional Chinese medicine therapies can regulate the gut microbiota，positioning it as a potential target for GERD intervention. |
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