| 引用本文:姚韵娟1，刘志鹏2，刘丽静3，王志强1，朱银杏2.中医五志与头痛关系的探究——一项孟德尔随机化研究[J].世界中医药,2025,(03):. |
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| 中医五志与头痛关系的探究——一项孟德尔随机化研究 |
| Causal Relationship between Traditional Chinese Medicine Five Emotions and Headache：A Mendelian Randomization Study |
| 投稿时间：2024-01-29 |
| DOI：10.3969/j.issn.1673-7202.2025.03.012 |
| 中文关键词: 孟德尔随机化分析 头痛 情志 因果关联 易怒 思虑过度 |
| English Keywords:Mendelian randomization analysis Headache Emotions Causal association Anger Overthinking |
| 基金项目:国家自然科学基金面上项目（82374220）；中国博士后科学基金第74批面上资助（2023M741796）；第四批江苏省名老中医药专家传承工作室建设项目（苏中医科教〔2021〕7号）；泰州市中医药科技项目（TZ202301） |
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| 中文摘要: |
| 目的：采用两样本孟德尔随机化研究中医五志与头痛的因果关系，探索头痛的潜在病因，为中西医治疗头痛提供新思路。方法：从全基因组关联分析（GWAS）数据库获取5种情志（怒、喜、思、悲、恐）及头痛、偏头痛和非偏头痛的其他头痛的汇总数据集，选择独立的单核苷酸多态性（SNP）作为每种疾病的工具变量（IVs）。采用逆方差加权法（IVW），加权中位数法（WME）、MR-Egger回归法探究五志与头痛之间的因果关系。使用MR-PRESSO进行离群值检测并矫正，Cochran Q检验进行异质性评估，Egger intercept法进行水平多效性检验，以保证结果的可靠性。结果：IVW结果表明头痛与易怒（OR=1.708，95%CI为1.079~2.703）、思虑过度（OR=1.647，95%CI为1.255~2.160）和悲伤抑郁（OR=1.535，95%CI为1.158~2.036）显著正相关；偏头痛与易怒（OR=1.017，95%CI为1.002~1.031）和思虑过度（OR=1.013，95%CI为1.002~1.021）正相关；非偏头痛与易怒（OR=1.010，95%CI为1.003~1.017）、思虑过度（OR=1.004，95%CI为1.001~1.008）和悲伤抑郁（OR=1.006，95%CI为1.003~1.010）具有潜在正相关。结论：易怒和思虑过度会增加头痛、偏头痛及非偏头痛的患病风险，悲伤抑郁会影响头痛和非偏头痛的发病。 |
| English Summary: |
| To investigate the causal relationship between the five emotions in traditional Chinese medicine(TCM) and headache by two-sample Mendelian randomization(MR)，aiming to explore potential etiologies and provide novel insights for headache treatment with TCM and Western medicine.Methods:Summary statistics for five emotions(anger，joy，overthinking，sadness，and fear) and headache-related conditions，including general headache，migraine，and non-migraine headache，were obtained from genome-wide association studies(GWAS) databases.Independent single nucleotide polymorphisms(SNPs) were selected as instrumental variables(IVs) for each condition.The inverse-variance weighted(IVW) method，weighted median estimator(WME)，and MR-Egger regression were used to examine causal relationships between the five emotions and headache.MR-PRESSO was applied for outlier detection and correction，Cochran's Q test was used to assess heterogeneity，and Egger intercept was employed to test for horizontal pleiotropy，ensuring the reliability of the results.Results:IVW analysis revealed that headache was significantly positively associated with anger(OR=1.708，95%CI 1.079 to 2.703)，overthinking(OR=1.647，95%CI 1.255 to 2.160)，and sadness/depression(OR=1.535，95%CI 1.158 to 2.036).Migraine was positively associated with anger(OR=1.017，95%CI 1.002 to 1.031) and overthinking(OR=1.013，95%CI 1.002 to 1.021).Non-migraine headache showed potential positive associations with anger(OR=1.010，95%CI 1.003 to 1.017)，overthinking(OR=1.004，95%CI 1.001 to 1.008)，and sadness/depression(OR=1.006，95%CI 1.003 to 1.010).Conclusion:Anger and overthinking increase the risk of developing headache，migraine，and non-migraine headache，while sadness/depression contributes to headache and non-migraine headache onset. |
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