| 引用本文:张丽丽1，常晓丽1，陈碧玮1，于成2，张海燕1，陈少宗1.肠道神经传导通路及针刺治疗肠易激综合征的相关神经机制与思考[J].世界中医药,2025,(03):. |
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| 肠道神经传导通路及针刺治疗肠易激综合征的相关神经机制与思考 |
| Intestinal Nerve Conduction Pathways and Neuromechanisms of Acupuncture Treatment of Irritable Bowel Syndrome：Insights and Reflections |
| 投稿时间：2024-01-22 |
| DOI：10.3969/j.issn.1673-7202.2025.03.016 |
| 中文关键词: 针刺 腧穴 肠易激综合征 肠道 神经 内脏高敏感性 肠道动力 系统科学 |
| English Keywords:Acupuncture Acupoints Irritable bowel syndrome Intestine Nerve Visceral hypersensitivity Intestinal motility Systems science |
| 基金项目:国家重点研发计划项目（2022YFC3500602）；国家自然科学基金青年基金项目（82205290）；山东省自然科学基金重大基础研究项目（2020Q006）；山东省自然科学基金项目（ZR202212030040）；山东省医药卫生科技发展计划项目（202302011716） |
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| 中文摘要: |
| 内脏高敏感性及肠道动力异常是肠易激综合征（IBS）的关键发病机制，而自主神经系统（交感及副交感神经系统）可介导肠道感觉及运动功能。通过梳理既往研究，发现针刺可以通过影响自主神经系统调控肠道感觉及运动，从而改善IBS内脏高敏感性、恢复肠道动力。治疗IBS的常用腧穴集中于躯干及下肢部，位于躯干部的腧穴与结肠交感神经通路关系密切，位于下肢的腧穴则与副交感神经通路联系紧密，但具体作用机制尚不清晰。肠道神经支配比较弥散，不同肠段交感神经和副交感神经分布比例存在差异。针刺治疗IBS的研究多集中于背根神经节、脊髓及脑水平，忽视了在外周交感干神经节的研究。针对针刺治疗IBS肠道动力的研究偏少，分子指标之间的作用关系缺乏研究，未来应借助系统科学深入研究分子信号间的相互作用过程，完整地揭示针刺治疗IBS的相关机制。 |
| English Summary: |
| Visceral hypersensitivity and abnormal gastrointestinal motility are key pathophysiological mechanisms of irritable bowel syndrome(IBS)，with the autonomic nervous system(ANS)—comprising the sympathetic and parasympathetic nervous systems—playing a crucial role in mediating gut sensation and motility.A review of existing studies suggests that acupuncture can regulate gut sensory and motor functions by modulating the ANS，thereby alleviating visceral hypersensitivity and restoring gut motility in IBS.Common acupoints for IBS treatment are primarily located on the trunk and lower limbs.Trunk acupoints are closely related to the sympathetic pathways of the colon，while lower limb acupoints are more closely associated with parasympathetic pathways.However，their precise mechanisms remain unclear.The innervation of the gut is diffusely distributed，with variations in the sympathetic and parasympathetic nerve distribution across different intestinal segments.Current acupuncture research on IBS mainly focuses on the dorsal root ganglia，spinal cord，and brain，with limited studies on the peripheral sympathetic chain ganglia.Additionally，studies on acupuncture's effects on gastrointestinal motility in IBS are relatively scarce，and the interactions among molecular indicators remain poorly understood.Future research should employ systems science approaches to explore the interplay of molecular signaling pathways，thereby providing a more comprehensive understanding of the mechanisms underlying acupuncture treatment for IBS. |
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