| 引用本文:杨俏丽1，荆鲁2，李梓荣1，刘尚建3，曹建春4.糖耐量减低伴发抑郁状态患者中医体质分布特点及危险因素分析[J].世界中医药,2025,(03):. |
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| 糖耐量减低伴发抑郁状态患者中医体质分布特点及危险因素分析 |
| TCM Constitution Distribution Characteristics and Risk Factors of Patients with Impaired Glucose Tolerance Complicated by Depressive States |
| 投稿时间：2024-04-16 |
| DOI：10.3969/j.issn.1673-7202.2025.03.017 |
| 中文关键词: 糖耐量减低 糖尿病前期 脾瘅 抑郁状态 中医体质 危险因素 分布特点 临床表现 |
| English Keywords:Impaired glucose tolerance Prediabetes Spleen-heat syndrome Depressive state Traditional Chinese medicine constitution Risk factors Distribution characteristics Clinical manifestations |
| 基金项目:国家重点研发计划“中医药现代化研究”重点专项（2019YFC1710101）；国家自然科学基金面上项目(81874473) |
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| 中文摘要: |
| 目的：探讨糖耐量减低伴发抑郁状态患者中医体质分布特点并分析其危险因素。方法：将2021年01月至2021年12月在北京中医药大学多家附属医院行口服葡萄糖耐量试验检查并进行中医体质辨识的患者作为观察对象，收集性别、年龄、婚姻状况、亲友联系、文化程度等基本资料，有效病例共487例，其中糖耐量减低伴发抑郁状态患者为85例，观察糖耐量减低伴发抑郁状态患者中医体质分布情况并通过Logistic回归分析筛选影响因素。结果：IGT伴发抑郁状态患者最常见的临床表现为躯体性焦虑，占比为90.59%；精神焦虑次之，占比84.71%。中医体质分布占比由高到低依次为痰湿质（18.82%）、平和质（15.29%）、湿热质（14.12%）、气虚质（10.59%）、气郁质（10.59%）、血瘀质（4.71%）、特禀质（3.53%）、阴虚质（2.35%）。单因素分析结果表明，性别、性格、健康教育、平和质、气郁质、痰湿质在IGT伴发抑郁状态患者与IGT不伴抑郁状态患者之间差异有统计学意义（P<0.05）；进一步Logistic回归分析发现，女性（OR=2.057）、急躁易怒性格（OR=2.306）是IGT伴发抑郁状态的危险因素（P<0.05），气郁质（OR=4.209）、痰湿质（OR=1.887）是IGT伴发抑郁状态的危险体质（P<0.05），而平和质（OR=0.214）是IGT伴发抑郁状态的保护体质（P<0.05）。结论：气郁质、痰湿质是糖耐量减低伴发抑郁状态的易感体质；性别、性格是糖耐量减低伴发抑郁状态的危险因素。 |
| English Summary: |
| To investigate the distribution characteristics of traditional Chinese medicine(TCM) constitutions in patients with impaired glucose tolerance(IGT) complicated by depressive states and analyze the associated risk factors.Methods:Patients who underwent an oral glucose tolerance test and TCM constitution identification at multiple affiliated hospitals of Beijing University of Chinese Medicine from January to December 2021 were enrolled.Basic demographic information，including gender，age，marital status，social connections，and education level，was collected.A total of 487 valid cases were included，among which 85 patients had IGT complicated by a depressive state.The TCM constitution distribution in these patients was analyzed，and logistic regression was used to identify influencing factors.Results:The most common clinical manifestation in patients with IGT complicated by a depressive state was somatic anxiety(90.59%)，followed by psychological anxiety(84.71%).The distribution of TCM constitutions，from highest to lowest prevalence，was as follows：phlegm-dampness(18.82%)，balanced constitution(15.29%)，dampness-heat(14.12%)，qi deficiency(10.59%)，qi stagnation(10.59%)，blood stasis(4.71%)，special diathesis(3.53%)，and yin deficiency(2.35%).Univariate analysis indicated that gender，personality traits，health education，balanced constitution，qi stagnation，and phlegm-dampness constitution showed significant differences between IGT patients with and without depressive states(P<0.05).Further logistic regression analysis revealed that female gender(OR=2.057) and an irritable temperament(OR=2.306) were risk factors for IGT complicated by depressive states(P<0.05)，while qi stagnation(OR=4.209) and phlegm-dampness(OR=1.887) were susceptible constitutions for IGT complicated by depressive states(P<0.05).Conversely，a balanced constitution(OR=0.214) was a protective factor(P<0.05).Conclusion:Qi stagnation and phlegm-dampness constitutions are susceptibility factors for IGT complicated by depressive states，while gender and personality traits are significant risk factors. |
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