| Based on the unique theory of “state-target syndrome differentiation” created by Academician TONG Xiaolin,this study explores the pathogenesis and treatment strategies for salt-sensitive hypertension(SSHT).It is proposed that the core pathogenesis of SSHT is “water retention and static blood obstructing collaterals”,which aligns with the modern medical understanding of SSHT involving water-sodium retention and vascular endothelial injury.On the basis of macro-level syndrome differentiation and state identification in traditional Chinese medicine(TCM),combined with modern pharmacological findings of micro-level disease differentiation for identifying targets,the theory regards “water retention and static blood obstruction” as the state and symptoms such as dizziness,edema,hypertension,and reduced nitric oxide(NO) levels as the targets.Wuling Powder is recommended as target formula to promote yang,transform qi,dispel water,and alleviate water retention.Leonuri Fructus,Salviae Miltiorrhizae Radix et Rhizoma,and Lycopi Herba can activate blood,resolve stasis,promote diuresis,and reduce swelling,serving as target drugs.This integrated approach can achieve the effects of transforming qi,moving water,activating blood,and dredging collaterals,thereby simultaneously regulating state and targets.This method can eliminate the root cause,regulate blood pressure based on syndrome differentiation,and provide symptomatic relief,offering a reference for clinical application of TCM in treating SSHT. |
