| 引用本文:张凌威1，2，郑入文2，图娅1，3，王瑜4，陈璐5，姜会梨1，3.从肠道菌群紊乱视角探讨疏肝和胃防治抑郁症的思路[J].世界中医药,2025,(03):. |
|
| 从肠道菌群紊乱视角探讨疏肝和胃防治抑郁症的思路 |
| Ideas of Liver-soothing and Stomach-harmonizing Therapy to Prevent and Treat Depression from the Perspective of Gut Microbiota Dysbiosis |
| 投稿时间：2023-04-07 |
| DOI：10.3969/j.issn.1673-7202.2025.03.020 |
| 中文关键词: 抑郁症 肝胃不和 肠道菌群 疏肝和胃 下丘脑-垂体-肾上腺轴 单胺类神经递质 细胞因子 脑源性神经营养因子 |
| English Keywords:Depression Liver and stomach disharmony Gut microbiota Liver-soothing and stomach-harmonizing therapy Hypothalamic-pituitary-adrenal axis Monoamine neurotransmitter Cytokine Brain-derived neurotrophic factor |
| 基金项目:国家自然科学基金青年科学基金项目（81904313）——针刺对抑郁症小胶质细胞M1/M2型极化紊乱诱导神经炎症的调控机制研究；国家自然科学基金面上项目（81973937）——“治病求本”：针刺干预抑郁/焦虑“共病”上游关键效应机制研究 |
|
| 摘要点击次数: 9 |
| 全文下载次数: 0 |
| 中文摘要: |
| 抑郁症是当代重大精神疾患，肝胃不和是其重要的中医病机。近年来研究发现，肠道菌群紊乱与抑郁症发病具有一定相关性，而中医“肝”和“胃”功能与肠道菌群的功能特性具有许多共通之处。研究表明，肝胃不和的本质可能与肠道菌群紊乱有关，临床多采用疏肝和胃法不仅能有效改善焦虑抑郁的症状，缓解精神障碍，还可调节肠道菌群功能。本文拟从肠道菌群紊乱的角度，探讨疏肝和胃法论治抑郁症的作用机制，以期为抑郁症的临床防治提供新的思路和证据。 |
| English Summary: |
| Depression is a major contemporary psychiatric disorder，with liver-stomach disharmony being an important pathogenesis in traditional Chinese medicine(TCM).Recent studies have found a certain correlation between gut microbiota dysbiosis and the onset of depression，and there are many commonalities between the functional characteristics of the TCM concepts of the “liver” and “stomach” and those of the gut microbiota.Research suggests that the essence of liver-stomach disharmony may be related to gut microbiota dysbiosis.Clinically，the liver-soothing and stomach-harmonizing therapy is widely used，not only effectively alleviating anxiety and depressive symptoms and mitigating mental disorders but also regulating gut microbiota function.This paper aims to explore the mechanism of the liver-soothing and stomach-harmonizing therapy in the treatment of depression from the perspective of gut microbiota dysbiosis，providing new insights and evidence for the clinical prevention and treatment of depression. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
