世界中医药
文章摘要
稳心颗粒对家兔左心室内、外膜电生理特性的影响
Effect of Wenxin Granule on Electrophysiological Characteristics of Adventitia and Endomembrane in Rabbit
投稿时间:2007-04-12  
DOI:
中文关键词: 心律失常/中医药疗法  @ 步长稳心颗粒
英文关键词: Arrhythmia/Chinese medical therapy  @Buchang wenxin granule
基金项目:
作者单位
崔长琮 西安交通大学第一附属医院西安市雁塔西路277号710061 
摘要点击次数: 2346
全文下载次数: 1215
中文摘要:
      目的:通过研究步长稳心颗粒对家兔左心室内、外膜电生理特性的影响,探讨步长稳心颗粒抗心律失常的机制。方法:应用浮置玻璃微电极记录技术,在不同频率刺激下,记录应用步长稳心颗粒前后家兔左室游离壁内、外膜心肌细胞跨膜动作电位(TAP)各种参数的变化。结果:(1)步长稳心颗粒延长内、外膜心肌细胞的动作电位时程(APD),当基础周长(BCL)为1000ms时,使用步长稳心颗粒后心内膜层肌细胞的APD90由(216±15)ms延长为(243±8)ms(P<0.01),外膜层肌细胞的APD90由(182±11)ms延长为(228±10)ms(P<0.01)。(2)步长稳心颗粒能显著缩短心室跨壁复极离散度(TDR),当BCL为1000ms时,用药后TDR由(33±9)ms减小为(21±10)ms(P<0.01)。结论:步长稳心颗粒可延长内外膜心肌细胞的APD,缩短左室TDR。
英文摘要:
      to investigate the anti-arrhythmia mechanism of Wenxin Granule by studying its effects on electrophysiological characteristics of adventitia and endomembrane in rabbit.Methods:capillary glass microelectrode was used for recording change of TAP parameters under different stimulation frequency.Results:(1) the granule could prolong action potential duration(APD). When basic cycle length (BCL)reached 1000ms, APD90 of endomembrane rose to (243±8)ms from (216±15)ms(P<0.01), adventitia APD90 were up at (228±10)ms from (182±11)ms. (2) the granule could remarkably cut down TDR. When BCL reached 1000ms, TDR was (21±10)ms from (33±9)ms(P<0.01).Conclusion:Buchang Granule can prolong APD of adventitia and endomembrane and reduce TDR of aortic ventricle of heart.
查看全文   查看/发表评论  下载PDF阅读器
关闭