To observe the clinical curative effect of Shenrong Zhuyang Wan (Shenrong Zhuyang Pills) on treating erectile dysfunction due to kidney yang deficiency.Methods: 121 cases of erectile dysfunction were randomly divided into Shenrong Zhuyang Wan (Shenrong Zhuyang Pills) group (60 cases,treated by Shenrong Zhuyang Wan) and Wuzi Yanzong Wan (Wuzi Yanzong Pills) group (61 cases,treated by Wuzi Yanzong Wan),and the relevant indexes were observed after 8 weeks.Besides,animal models with kidney yang deficiency were set up and given different doses of Shenrong Zhuyang Wan(Shenrong Zhuyang Pills)(large dose,mediate dose and small dose) as well as a great amount of Qiangshen Pian (Qiangshen Tablets) and distilled water respectively,so as to observe the changes of indexes before and after medication,including changes of genital organ index,incubation period for penile erection,copulation times in a unit time and survival time in low temperature,etc.Results: In Shenrong Zhuyang Wan (Shenrong Zhuyang Pills) group,7 cases were cured,28 cases got obvious curative effects,20 cases got positive effects and 5 cases with no obvious effect,and total effective rate being 91.67%.As far as total effective rate and improvements of symptoms of fatigue and short of strength as well as aversion to cold and cold limbs were concerned,Shenrong Zhuyang Wan (Shenrong Zhuyang Pills) group was better than control group.Besides,Shenrong Zhuyang Wan (Shenrong Zhuyang Pills) group was turned out to be non toxic and no side effects.Shenrong Zhuyang Wan (Shenrong Zhuyang Pills) could improve the penis excitability of caponized rats towards external stimulus and shorten incubation period for penile erection.Compared to those of caponized rats of control group,the index number of samenblase plus prostate and organs as well as levator ani muscle of rats of Shenrong Zhuyang Wan(Shenrong Zhuyang Pills) group were enhanced,the copulation ability was obviously improved and the number of times of capture and ejaculation in a unit time was increased.In Shenrong Zhuyang Wan(Shenrong Zhuyang Pills) group of large dose,the survival time of swimming under a low temperature of 8℃ of rats with yang deficiency syndrome could be obviously prolonged.Conclusion: Being proved by clinical observation and animal experiment,Shenrong Zhuyang Wan(Shenrong Zhuyang Pills) has good curative effect on erectile dysfunction due to kidney yang deficiency and it can improve kidney yang deficiency syndrome.