To explore the functional mechanism of Longdan Jiangzhi Keli (Longdan Jiangzhi Particles) for treatment of fatty liver.Methods:Wistar rats were randomly divided into 6 groups,namely,the normal control group,model group with hyperlipemia,group using jiang zhi ling,and Longdan Jiangzhi Keli(Longdan Jiangzhi Particles) treated groups of three kinds of dosage,which was 14 g/kg,7 g/kg and 3.5g/kg respectively.Except for the normal control group,other groups were fed with high fat food and given intragastric administration once every morning,lasted for 4 weeks.Results:Longdan Jiangzhi Keli(Longdan Jiangzhi Particles) could obviously reduce the content of total cholesterol,triglyceride and the low density lipoprotein in sera of rats with hyperlipemia and increase the content of high density lipoprotein,which manifested a strong effect on reducing blood fat.Besides,it had cholagogue effect,the choleresis increased within 1～3 hours after medication and the rate of increase could reach as high as 50%.Additionally,it also had remarkable inhibitory function for the proliferation of cotton ball like granulation tissue.Conclusion:Longdan Jiangzhi Keli(Longdan Jiangzhi Particles) can reduce blood fat and show choleretic effect.