To observe the clinical curative effect of the method of regulating governor vessel and removing blood stasis and expelling toxin for treatment of uremia at advanced stage.Methods:92 cases of uremia at advanced stage were randomly divided into two groups.The treatment group (n=48) were treated with conventional therapy plus applying powder of Chinese materia medica on governor vessel,Shu acupoint of five zang and six fu organs of bladder channel of foot greater yang (BL),three times a day and one hour for each time,and the control group(n=44) were treated with conventional therapy.Results:The total effective rate and biochemical indicator of treatment group are significantly better than those of control group (P<0.05).Conclusion:By using method of regulating governor vessel and removing blood stasis and expelling toxin,the clinical curative effect of the patients of uremia at advanced stage can be improved.