To explore the clinical curative effect of the therapy of integrated Chinese and western medicine on treatment of diabetic nephropathy at azotemic stage (DNAS).Methods:67 cases of DNAS with serum creatinine level at 265μmol/L were randomly divided into 2 groups (32 cases in Group A and 35 cases in Group B).Patients of group A were treated by the therapy of routine multifactorial potentialized control (MPC) of blood sugar,blood pressure and blood fat with western medicine.Patients of group B were treated by MPC therapy plus some Chinese materia medica with function of supplementing Qi,tonifying kidney,activating blood circulation and repelling toxin.Another group of patients of DNAS with serum creatinine level between 385～517 μmol/L (Group C) were treated with MPC therapy and Chinese materia medica referred above as well as the therapy of retention enema of decoction of Chinese materia medica.All the patients mentioned above were given low protein diet plus a keto acid therapy.Results:After treatment,levels of Serum creatinine (Scr),Blood Urea Nitrogen(BUN),Endothelin 1(ET 1) and quantitative examination of 24hour urinary protein of patients of group A were obviously reduced (P<0.05 or P<0.01).Levels of Scr,BUN,ET 1 and 24hour urinary protein of patients of group B and group C were significantly reduced after treatment(P<0.01).Conclusion:For patients of DNAS,the therapy of lpd with aka plus MPC with western medicine were able to effectively reduce the levels of Scr,BUN,ET 1 and 24hour urinary protein.On the basis of MPC therapy,the results of treatment were even better after adding Chinese materia medica with function of supplementing Qi,tonifying kidney,activating blood circulation and repelling toxin.For the patients of DNAS whose Scr level were comparatively higher (such as patients of group C),the treatment with integrated Chinese and western medicine as well as the therapy of retention enema of decoction of Chinese materia medica also produced satisfactory curative effect.