To describe second-year students at a key university of Shanghai for the epidemic strength of personality deviation and personality disorders. Methods:Personality Diagnostic Questionnaire-Revised (PDQ-R), International personality disorder Examination (IPDE) and general survey questionnaires were used in the survey. Results: PDQ-R total score of 1846 college students was (19.8±7.6)with a positive rate of 5.92%; 46 cases were finally diagnosed personality disorder，about 3.41% of the total; obsessive-compulsive personality disorder held the highest attack rate(1.73%)and constituent ratios(31%). Conclusions: College students are more likely to have personality disorders. Bitter growing environment, such as antagonistic family environment, single parent, low family income, single child and low educational level of parents, all played an important role in the formation of personality disorders.