Abstract:to investigate into differences among various sign-syndrome type of hepatic fibrosis following chronic hepatitis B virus(HBV), and the most common type to bring to light internal relations between nature of sign-syndrome and objective indices. Methods:By case observation and lab detection, 152 confirmed patients’ clinical information, (i.e., case history, symptoms, syndrome differentiation, assisted tests-ALT, AST, HBV-DNA, HA, type Ⅲprecollagen, type Ⅴcollagen, and LN) were collected and processed with SPSS13.0 software. Results:152 cases were categorized into different sign-syndrome types: 112 cases (73.68%)into the type of liver depression and spleen deficiency (a); 20 cases (13.16%) into damp-heat obstruction(b);16 cases (10.53%) into blood stasis and collateral obstruction(c); 3 cases(1.97%) into yin deficiency of liver and kidney(d); 1 cases (0.66%) into yang deficiency of spleen and kidney(e).Cases with positive results in hepatic fibrosis tests mostly belonged to type a; PCIII level: d>a>c>b;C1-IV:c>a>b>d; LN: a>b>d>c; HA: c>a>d>b. However, any two types were not significantly different in fibrosis tests(P>0.05).Conclusions:liver depression and spleen deficiency(a) is most common in chronic HBV caused hepatic fibrosis. Types of a, b, c, d, e in order were different illness developing phases. As illness aggravates, hepatic fibrosis increases, while number of positive cases in HF tests declines, in the same time, the levels of PCIII,C1-IV,LN,HA rise gradually.