to evaluate therapeutic efficacy of Channel-Soothing Collateral-Activating Lotion plus Type A Botulinus Toxin Injection on spasticity in ankle-Plantar flexors following apoplexy. Methods:According to inclusion criteria, 29 cases were recruited in the study and randomly grouped to be treated with the Lotion plus the Injection (treatment group, n=15) or with the Injection only (control group, n=14). Both groups took rehabilitation training. The efficacies were evaluated by Modified Ashworth Scale (MAS), stride length, walking velocity at the baseline, 2-week, 4-week, and 8-week after treatment. Results:The treatment group scored higher than the control group in all indices after 4 and 8 weeks (P<0.05). Both groups improved in all indices after treatment. Conclusions:Channel-Soothing Collateral-Activating Lotion plus Type A Botulinus Toxin Injection is very efficacious in treating spasticity in ankle-Plantar flexors following apoplexy, and better than Type A Botulinus Toxin Injection only.