to observe the clinical curative effect of Xianlong Dingtong Yin on osseous metastasis caused pain using random control studies.Methods:60 cases with Osseous Metastasis were randomly divided to treatment group(30 cases) to be treated with the drink and Morphine sulfate and control group(30 cases)to be treated with Morphine sulfate alone. When effective rates (CR+PR) reached 50%, changes of quality of life (PS rating, FLIC), side effects, dosage of Morphine sulfate were compared before and after treatment.Results:both groups significantly improved in FLIC (P<0.01), while the difference between them was significant (P<0.01); treatment group was significantly better than control group in gastrointestinal reaction and nervous system(P<0.05); conventional and maximum dosage of Morphine sulfate were significantly different.Conclusion:the drink has significant curative effects for osseous metastasis caused pain, improving quality of life, reducing dosage of morphine related drugs, in which side effects can be reduced.