to investigate the action mechanism of Danhong Injection on cardio-cerebral-vascular disease. Method:Anticoagulation effect of the Injection was investigated using parameters such as maximum platelet aggregation rate, wet weight of thrombus, inhibitive rate of cerebral thrombosis, and hemorheological parameters, etc. Results:Danhong Injection at all doses studied could significantly reduce rates of platelet aggregation in rabbits, improve hemorheology of rats of acute blood stasis, and inhibit cerebral thrombosis, and lower wet weight of thrombus. Conclusion:Danhong Injection has marked anticoagulative effect.