Observations of physical signs (sgs) corresponding with meridians and acupoints can assist tests for blood and urine glucose. Summarized in this article are the basic laws of the diagnostic method of meridians and acupoints sgs corresponding with diabetes, in particular, how cold, hot, deficiency, excess of acupoints can mirror nature of the disease. The reflection is subjected to subtle changes, and selection of acupoints for examination is varied along with progress of illness. Drawn on clinic experience the author concluded physical signs of meridians and acupoints was helpful in insulin resistance, reduction of BG, control and treatment of diabetic complications.