Infrared thermal imaging (ITI) has potential for application in the health care field of Chinese Medicine. This double-blind randomized study explored its application and feasibility in this field.Methods:The subjects were male university students with weak constitution. Shengsheng capsule, a kind of TCM health food with immunity adjustment function, was taken by the trial group while placebo by the control group for 108 days. Four ITI features (the superior part feature, central part feature, inferior part A feature and inferior part B feature) were observed.Results:The results showed that the effect of Shengsheng capsule on the human body could be reflected objectively by ITI. On d 6, significant difference between the two groups had been observed in the superior part feature. The effect of Shengsheng capsule on people with weak constitution or in the period of being weak could also be reflected. The relative efficacy rate was 81.3% for the trial group and 30.0% for the control group, there was significant difference between the two groups (P=0.003).Conclusions:ITI's feature of sensitivity and objectivity made its application very significant and applicable in the health care field of Chinese medicine.