To observe the clinical effectiveness of Ultramicro Compound Huadu Paste on acute oncotic ulcer (AOC), and investigate action mechanism by animal tests.Methods:One hundred and thirty in-and outgoing AOC patients were randomly grouped to the treatment group, control A group, control B group to be treated with the ultramicro paste, the traditional paste, Ciprofloxacin respectively, and rated on symptoms and physical signs. Rat model was established using paw-swelling tests and observed on blood perfusion, concentration of blood cells, velocity of blood flow, skin temperature, swelling of paws.Results:The cure rate and total effective rate for treatment group were 76% and 96%, 48% and 94% for the control A group, 33% and 67% for the control B group. Conclusion:The external preparation of Chinese medicine -Ultramicro Compound Huadu Paste has more significant anti-inflammatory effect than the traditional Paste in treatment of acute oncotic ulcer.