To investigate therapeutic effectiveness of Sheng Bai Hewei holothurians Oral Liquid in treatment of chem-induced leucopenia.Methods:126 malignant tumor cases were randomly grouped to the treatment group (43 cases) orally taking the liquid, the control A group using Batilol and Vit.B₄, and the control B group injected with rh-GSF.Results:The total effective rate and obvious effective rate were 90.7% and 60.5% respectively in the treatment group, those of the control A group were 78.0% and 43.9%, of the Control B group were 95.2% and 73.8% respectively. Those of the treatment group and of the Control B group were not significantly different from each other (P>0.05) and they were in comparison with those of the control A group (P<0.01). In the treatment group，WBC, HB, and BPC were very significantly higher after treatment (P<0.01), while the chemo completion rate and KPS rating were very significantly improved than those of Control A group (P<0.01).Besides, incidence rates of nausea and vomiting, of HB decrease, of BPC decrease were significantly lower than those of the Control B group (P<0.05). Conclusions:Sheng Bai Hewei holothurians Oral Liquid can alleviate toxic or side effects of chemotherapy in malignant tumor by raising WBC level.