To observe the intervention of Mass-Clearing Extraction (per rectum) on hysteromyoma apoptosis of rat model.Methods:hysteromyoma models were established on SD female rats according to Fujii S methods，and randomly divided to 5 groups，ie. The model group，high-dosage，middle-level dosage，low-dosage group of the extraction，the control group (administered on Guizhi Fuling Jiaonang，Cinnamon Twig and Poria Capsule). Estradiol levels were detected by radio-immunity method; pathomorphological changes and expression of Bcl-2，a gene of apoptosis were observed by immune histochemistry methods.Results:high dosage of the extraction can inhibit tumor related accrementition (P<0.01)，and bring down estrin level (P<0.01). In the model group there were increased counting of positive cell of Bcl-2，intensified positive signal and more expression of Bcl-2 (P<0.01).Conclusion:Mass-Clearing Extraction can diminish hysteromyoma by inducing apoptosis of hysteromyoma，reducing Bcl-2 positive expression and inhibit hysteromyoma accrementition.