To observe the effect of Xue zhi kang on serum levels of high-sensitivity C-reactive protein (hs-CRP)、matrix metalloprotease in patients with acute coronary syndromes (ACS), and discuss how those factors correlate with ACS.Methods:Fifty-four patients with ACS were randomly divided into two groups: Xue zhi kang group and atorvastatin group. At the same time,10 cases of age matched ACS were selected as a control. The serum level of hs-CRP, cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),MMP-2 and MMP-9 were measured before and after treatment.Results:After one week treatment, there were significant reduction of all above serum levels in Xue zhi kang group and atorvastatin group when each was compared with the control group (P<0.05). However, there was no significant difference between Xue zhi kang groups and atorvastatin groups (P>0.05).Conclusion:1) MMP-2 and MMP-9 hs-CRP can be used as diagnostic indicator of unstable plaque; 2) Xue zhi kang can relieve blood fat, lower the levels of such ACS inflammatory factors as hs-CRP, MMP-9 and MMP-2, and produce similar effect of anti- artherosclerosis and stabilizing plaque as atorvastatin.