The multi-drug therapeutic regime, Fluoxetine plus self-prescribed Chinese medicinal decoction of depression-relieving, was compared with Fluoxetine for the efficacy for female menopausal depression.Methods:Sixty-eight female patients with menopausal depression were randomly assigned to the two treatments for a course of 4 weeks, and evaluated according to Hamilton depression scale (17 items, HAMD).Results:At the end of treatment, the total effective rates and scores of HAMD scale turned out significant differences among the two groups.Conclusion:The multi-drug therapeutic regime of Fluoxetine plus self-prescribed Chinese medicinal decoction of depression-relieving was more effective than using Fluoxetine alone for treatment of depression.