To observe the effect of integrated Chinese and western medicine on chronic severe hepatitis B.Methods:Eight-six cases were divided at random to treat group (n=43), who received a combined regime of routine western treatment and Chinese formulas, and control group (n=43) who were given routine western treatments only. Survival rate, mortality rate, liver function and PTA were measured before and after treatment. Results:Survival rate for the treat group was 72.1% compared with 55.9% for the control group. For the treat group, ALT, TBil, Alb, PTA were significantly lowered and liver functions improved compared with those of the control group (P<0.05).Conclusion:Integrated Chinese and western medicine is effective for treating Chronic severe hepatitis B.