To observe the effectiveness of Zhishi Xiaopi tang on non-alcoholic fatty liver of phlegm-dampness.Methods:The 30patients with non-alcoholic fatty liver of phlegm-dampness were given Zhishi Xiaopi tang compared with 28 patients receiving Polyene Phosphatidylcholine for 12 weeks. Recorded before and after treatment the patients’ symptoms, blood fat (TG、TC、HDL-C), liver function (ALT、AST、GGT), body mass index (BMI), waist-to-hip ratio(WHR). Results:After 12-week treatment, the treat group showed statistically different results of TG、TC、HDL-C、ALT、AST、GGT、BMI compared with those of the control group.Conclusion:Without signs of adverse effect, Zhishi Xiaopi tang significantly lowered the levels of TG、TC、HDL-C, improved liver functions, and reduced BMI and WHR for patients with non-alcoholic fatty liver of phlegm-dampness.