To research condition of blood circulation in rats with liver depression and spleen deficiency.Methods:To establish such illness model, we placed plastic clip onto rats’ tails to cause fighting, fed food every other day while keeping food in sight during fasting, measured TXB₂、6-Keto-PGF_1α、calculated ratio of TXB₂/6-Keto- PGF_1α. Results:Compared with normal rats, the model group had higher ratio of TXB₂/6-Keto-PGF_1α along with an increase in TXB₂ (P<0.05), 6-Keto-PGF_1αdidn’t change significantly (P>0.05).Conclusion:The disproportionate relationship between TXA2 and PGI2 increase risk of thrombus in rats with liver depression and spleen deficiency, suggesting hampered or stagnant blood circulation.