Discussed is the connotation and the practical significance of “If the primordial qi of one's five zang-organs are smooth, one will enjoy good health”, a thought proposed by Zhang Zhongjing in Jin Gui Yao Lüe (Synopsis of the Golden Chamber). Methods:Our research is based on literature study. Conclusion: The five zang-organ systems maintain harmony and integration with the environment through common material foundation of the “primordial qi”, the free movement of which is the reflection of a healthy body, thus provides a feasible solution to intractable diseases.