To observe the impact of Buchang Naoxin Tong on the thickness of carotid tunica media and the hemorheologic changes in type Ⅱ diabetes. Methods:One hundred and twenty patients with type Ⅱ diabetes were randomly grouped to receive, in addition to the basic treatment, Buchang Naoxin Tong or Compound Danshen Dripping Pills respectively. We observed the thickness of carotid tunica media and the hemorheologic changes of the patients, before the treatment and on 8-week treatment. Results:Both medicines could improve blood rheology and reduce the thickness of carotid tunica media. Buchang Naoxin Tong showed better therapeutic effect (P<0.05). Conclusion: Buchang Naoxin Tong is effective for prevention and treatment of great vessel complications in type Ⅱ diabetes.