To observe the impact of Shuxuetong on the expression of P- selectin, L- selectin, and C-reactive protein in the condition of acute cerebral infarction, and study the intervention mechanism thereof . Methods:Eighty patients were randomized to receive Shuxuetong (6ml, diluted with 250ml 0.9% Sodium Chloride, once per day) plus routine treatments (anti-platelet aggregation, etc.) for 14 consecutive days, controlled by those receiving the routine treatments only (anti-platelet aggregation, etc.).The clinical effect, P-, L- selectin, and CRP were observed. Results:The significant effective rate (72.5%) and effective rate of (92.5%) of the treatment group were higher than those of the control group (50%, 75%, P<0.05). After treatment, both groups improved in all abovementioned parameters (P<0.05), with the treatment group being significantly better (P<0.05). Conclusion: By intervening the expression of P- selectin, L- selectin, and regulating inflammatory reaction, Shuxuetong Injection has satisfactory therapeutic effect on acute cerebral infarction.