To explore the in vivo antibacterial and antivirus effects of Waigan Fengsha Tablets for respiratory infection, and its effect on cough and phlegm on the animal models.Methods:The anti-infection effects were examined in vivo, positive controlled experiments and amelioration of cough and phlegm were observed on mice induced by ammonia.Results:The tablets has remarkable protective effects for mice contracted with Staphylococcus aureus, Staphylococcus epidermidis, or viral pneumonia, prolongs latent period for cough, and increases expectoration.Conclusion:Waigan Fengsha Tablets has significant antibacterial, antiviral, cough-stopping effects.