To observe efficacy of the method of pattern differentiation and treatment on chronic fatigue syndrome(CFS). Methods:Sixty patients were differentiated in terms of TCM patterns, then took respective TCM compound granules corresponding with the syndrom. Results:The total effective rate was 93.3%: among all the cases treated, 23 patients recovered (38.3%), 24 patients had significant improvements (40%), 9 patients were partially alleviated of the symptoms (15%). Conclusion: Chronic fatigue syndrome responded satisfactorily to the method of pattern differentiation and treatment.