To compare efficacy and adverse effect of a chemo therapy (Capecitabine + Oxaliplatin) and the therapy plus spleen invigorating and mass resolving TCM medicines for advanced esophageal cancer relapse.Methods:Seventy six patients with advanced esophageal cancer relapse and past PF chemo treatment, were randomly divided to the TCM group (38 cases) and control group (38 cases) to receive the TCM medicine, or Vitamin B6 respectively in addition to the chemo treatment.Results:The effective rate of the TCM group (71.1%) was significantly higher than that of the control group (44.7%, P<0.05). Such adverse effect as vomiting, diarrhea, anaemia, plate-reduction, liver impairment, aleucocytosis, hand-foot syndrome, alopecie; neurotoxicity were also significantly reduced in the TCM group compared to the control group.Conclusion:Spleen invigorating and mass resolving TCM medicine can enhance efficacy and reduce adverse effect of the chemo treatment for advanced esophageal cancer relapse.