To evaluate the efficacy of a new dosage form of Qishen medical formula for treatment of atherosclerosis of coronary heart disease. Methods:In a randomized, double-blind control clinical research, a comparison was made between the original form of Qishen (111 cases) and the present forms of Qishen (108 cases).Results:The efficacy of the medicaments, measured as symptom alleviation, TCM pattern relief, ECG improvement were not significantly different between the two groups (P>0.05); after treatment, abnormal levels of TC and TG were decreased significantly (P<0.05) for each group, with no statistically difference between groups (P>0.05). Conclusion:The new dosage form of Qishen, processed with new technology, has a similar potency to the original dosage form.