To observe impact of Yuzhuoqing Granule, which is formulated according to the stasis resolving and liver-kidney benefiting principle, on hypertensive rats and the mechanism.Methods:To establish the hypertension model by routine methods on male SD rats, which were randomly grouped to receive distilled water (group A), or the granule at high dosage (group B)/ low (group C) dosage for consecutive 28 days. Take blood pressure for 4 times. After 4 day interruption, resume the same medication with one modification: group A and C took Captopril 50mg／kg in addition. Take blood pressure for 4 times. Measure blood viscosity, erythrocyte aggregation and RCD.Results:After 28 day, the parameters of group C and B showed significant differences when compared with those before treatment, respectively (P<0.05，P<0.01); Group B was even better than group C and group B (P<0.05，P<0.01).Conclusion:Yuzhuoqing Granule has significant anti-hypertension effect on rat models. As shown by prolonged treatment courses, Yuzhuoqing Granule plus Captopril is more effective than each one of them.