To evaluate efficacy of syndrome based tonic syrup for intervention of sub-health.Methods:In the 3-month trial, after randomization, treatment group (n=50) took tonic syrup made up for individual patient, control group(n=50) took fixed tonic syrup (Shiquandabu Tang).Results:Post-treatment sub-health scores of both groups were lower than respective scores prior to treatment (P<0.01); On average, control group scored lower than control group after treatment.Conclusion:Compared with fix tonic syrup, syndrome based tonic syrup has better efficacy for sub-health.