To assess the clinical value of Segmentation and ligation for severe mixed hemorrhoids.Methods:A prospective randomized trial(n=60) for treating severe mixed hemorrhoids comparing Segmentation and Ligation (SL group) and the approach of stripping off the varicose masses of the external hemorrhoids and ligating the internal (control group). Evaluation parameters include cure rate, hospitalization duration, healing time, operative time, postoperative complications and safety etc.Results:Cure rate was 90.0% of SL group and 86.7% of the control group. Significant differences (P<0.05) were shown in hospitalization duration, healing time, operative time, presence of pain, dropsy and redundant skin residue. In postoperative bleeding, urination difficulty, anal stenosis, there were significant difference between groups (P>0.05).Conclusion:Segmentation and ligation can significantly reduce hospital stay, healing time, operative time and presence of dropsy, maintain good physiological function of anus.