To evaluate efficacy of Qi- Yin Nourishing Method to treat diabetes with depression.Methods:Using randomization, treatment group took Qi- Yin Nourishing formula (ingredients: Huangqi, Taizishen, Chaihu, Zhiqiao, Baishao, Suanzaoren, etc.) in addition to basic treatment, control group took Fluoxetine hydrochloride, for 8 weeks.Results:Qi- Yin Nourishing formula can significantly improve HAMD score, alleviate such symptoms as lassitude, weakness, shortness of breath, melancholy, irritability, with a total effective rate of 83.33%, compared to 66.67% that of control group.Conclusion:Qi- Yin Nourishing formula is safe and effective for treating diabetes with depression, and suitable for clinical application.