Abstract:To observe protection of Tongmai Yangxin Pill on arrhythmia on animal models.Methods:The models were established on mice and rats respectively by chloroform and BaCl2, and given Tongmai Yangxin Pill, then observed latent time of heart arrest and fibrillation ventricular on mice model, and duration of arrhythmia on rats model.Results:Tongmai Yangxin Pill can significantly reduce fibrillation ventricular incidence, prolong CA latent period, shorten duration of BaCl2 induced arrhythmia, in particular the dosage of 4.0g/kg was preferable to 2.0 g/kg and 1.0 g/kg.Conclusion:Tongmai Yangxin Pill has good protective effect on arrhythmia on animal models.