To investigate effects of Danhong Injection on liver cirrhosis.Methods:Eighty-two patients with liver cirrhosis were randomized to two groups, i.e. control group (n=42) and treatment group (n=40). Danhong Injection was given to treatment group, as an add-on treatment to routine treatment, over a period of 30 days. At end of the treatment period, liver function and cirrhosis parameters(HA、LN、IV-C、PC-III) were observed. Results:Significant differences were measured between two group with plasma cirrhosis parameters (P<0.05 or P<0.01), but not with liver function parameters (TBil, ALT etc.). Conclusion: Danhong Injection can improve microcirculation of the patients with liver illness, decrease liver cirrhosis, thus present promising prospects.