To investigate effects and costs of Zhikang Capsule in combination with western Medicine for Helicobacter Pylori (Hp) to design rational corrective regimen for peptic ulcer.Methods:a grouped, positive-controlled study, and Pharmaco economics methods. Hp first eradicated patients(n=115) were grouped and received respective treatments over a period of 7 days: group A received Zhikang Capsule 0.6g Tid, Amoxicillin 0.5g Tid, Clarithromycin 0.25g Bid, Lansoprazol 30mg Bid. Group B: Zhikang Capsule 0.6g Tid. Group C: Group A minus Zhikang Capsule. Group D: 27 second eradiated patients, same regimen as group A. Results:eradicate rates for group A,B,C,D were respectively 93%,32%,94%,81%. Total AE rate= 16.2%. Differences between A and C, A and D were not significant (P>0.05). Differences between C and (A+D), C and B were significant (P<0.01). After 1 year of treatment, C and (A+D), C and B were significantly different in terms of ulcer occurrence rate and Hp infection (P<0.01), A and D not significantly different (P>0.05)。In terms of CEA analysis (IncrC/E, C/E), A was the most cost effective, C was the second best. Conclusion: Zhikang Capsule, as an add-on treatment can reduce ulcer rate and Hp infection rate after 1-year treatment, and A is the most cost effective.