To investigate effect of Arthritis pills on pathological changes of the adjuvant induced arthritis.Methods:The effect of Arthritis pills is evaluated in terms of joint swelling degree and pathological changes on adjuvant induced arthritis rat model. Results:Arthritis pills could significantly reduce swelling of rat toes; prevent destruction of bones, synovial and cartilage. And the effect is dose dependent. Conclusion: Arthritis pills can reduce swelling and inhibit synovial hyperplasia.