The reason why 60-year Modern research of Chinese medicine has not yet resolved the issue of methodology in the real world, is lack of appropriate methods. From the perspective of zang qi- time relationship, the author pointed out a common problem of research: Most studies have neglected the important correspondence between zang and time: four seasons pulse and its parameters is helpful to disclose zang qi- time relation. Taking circadian rhythms as an example, Cunkou pulse and its characteristic parameters can be a wonderful subject of research of Chinese medicine.