To observe efficacy of LongHua Capsule on treatment of thrombocytopenia after radiotherapy and chemotherapy. Methods:Sixty-four patients were randomized to treatment group (n=34) and control group (n=30). The treatment group was given LongHua Capsule orally (4 tablets /time, 3 times a day), the control group was injected IL-11 25μg/Kg daily at 13:00. The symptoms and peripheral platelet count changes were observed when all patients were treated continuously for 14 days or platelet count was greater than 100 × 109 /L whichever comes first. Results:Compared with the control group, the treatment group was better at symptom improvement and lower in peripheral platelet count on the Day7 (P<0.05). There was no significant change between the groups in peripheral platelet count and the total efficay on Day14 (P>0.05). Conclusion: LongHua Capsule can improve clinical symptoms and increase peripheral platelet count in patients with thrombocytopenia after chemotherapy.