To explore efficacy and safety of Ci Dan capsule for treatment of primary liver carcinoma of phaseⅣ.Methods:Patients of primary liver carcinoma of phaseⅣ (n=160) were open randomized to treatment group (n=86), to take Ci Dan capsules, 5 capsules each time, 4 times daily, and control group ( n=74) to take Ci Dan capsules on top of chemotherapy. After 3 courses of treatment (3 months), efficacy and safety of Ci Dan capsule were evaluated.Results:The control group was better in observed efficacy, phase classification, while the treatment was better liver and kidney functional improvement, hematology parameters and safety.Conclusion:Ci Dan capsule is effective and safe in the treatment of primary liver carcinoma.