To evaluate the efficacy and safety of Biyanning Granule on moderate to severe persistent allergic rhinitis.Methods:To compare efficacy, quality of life, safety of Biyanning and Cetirizine hydrochloride tablet on top of Budesonide nasal spray in 177 patients.Group A was treated with Budesonide nasal spray, group B with Budesonide plus Biyanning Granule, group C with Budesonide plus Cetirizine hydrochloride tablet.Results:After one week,the effective rates of group A, B and C was 47％,67％ and 74％,and there was significant difference between group A and B or A and C(P<0.05), but not significant between group B and C(P>0.05).After two weeks, the effective rates of group A, B and C was 60％, 79％ and 82％,there was significant difference between group A and B or A and C(P<0.05),but not significant between group B and C(P>0.05).There was significant improvement of quality of life after treatment for all groups (P<0.05).Quality of life of Group A was significantly better than that of group B or C, but not significant between group B and C.Without severe adverse reaction, the AE occurence rates were 13.3 %,15.3 % and 22.4 %.Conclusion:Biyanning Granule has corrective efficacy for moderate to severe persistent allergic rhinitis.The combined effect with Budesonide nasal spray is as good as Cetirizine Hydrochloride with less adverse drug reactions.