To investigate analgesic and anti- autoimmune arthritis effect of Gubi analgesic Cataplasms.Methods:The experiment was carried out on five groups: the low-dose group, the middle-dose group, the high-dose group, the Shexiang Zhuanggu Gao group, and the matrix control group.The main pharmacodynamic index was investigated by using rats and mice respectively for the test targets.Results:Gubi analgesic Cataplasms increased the pain threshold value of mice by hot-plate procedures, decreased twist times of mice, which was favorable indices for prevention and treatment of autoimmune arthritis, and significantly reduced foot size of immune arthritis, decrease the severity of arthritis.Conclusion:Gubi analgesic Cataplasms have confirmed analgesia and anti-autoimmune arthritis effect.