To investigate efficacy of Jinghua Weikang Granule in combination of standard triple therapy for treatment of chronic gastritis. Methods:A total of 148 HP positive gastritis patients were divided into two group. The treatment group (n=77) received Jinghua Weikang Granule in combination of standard triple therapy， and the control group (n=71) received standard triple therapy. Efficacy parameters include HP clearance rate， relief of clinical symptoms， effective rate and safety.Results:HP clearance rate was 77.9% and 62% respectively of treatment group and control group (P<0.05). The treatment group did better than the control group at relief of main symptoms.Conclusion:Jinghua Weikang Granule in combination of standard triple therapy showed better HP clearance， relief of clinical symptoms and effectiveness compared with those of the standard triple therapy， without obvious adverse event， therefore Jinghua Weikang Granule in combination of standard triple therapy is a new application of integrative Chinese and Western medicine to treat chronic gastritis.